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Adalat GITS拜新同

Adalat GITS

nifedipine

Manufacturer:

Bayer

Distributor:

Zuellig
/
Four Star
Concise Prescribing Info
Contents
Nifedipine
Indications/Uses
All grades of HTN. Prophylaxis of chronic stable angina pectoris, as monotherapy or in combination w/ a β-blocker.
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Dosage/Direction for Use
Mild to moderate HTN Initially 20 mg once daily, can be increased up to max 90 mg once daily. Severe HTN; prophylaxis of angina pectoris Initially 30 mg once daily, can be increased up to max 90 mg once daily. Patient switched from other Ca antagonist Initially 30 mg once daily.
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Overdosage
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Administration
May be taken with or without food: Swallow whole, do not chew/crush. Avoid grapefruit juice.
Contraindications
Hypersensitivity to nifedipine or other dihydropyridines. Cardiogenic shock, clinically significant aortic stenosis, unstable angina, during or w/in 1 mth of MI. Not for the treatment of acute attacks of angina. Not for secondary prevention of MI. Safety has not been established in malignant HTN. Concomitant administration w/ rifampicin. History of GI obstruction, oesophageal obstruction, or any degree of decreased lumen diameter of GI tract; inflammatory bowel disease or Crohn's disease. Patient w/ a Kock pouch. Hepatic impairment.
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Special Precautions
Patients w/ hypotension; poor cardiac reserve; diabetes. Reports of heart failure deterioration. Risk of marked BP reduction in dialysis patients w/ malignant HTN & hypovolaemia. Possible postural hypotension w/ β-blocking drugs & other antihypertensives. Excessive BP reduction in pregnant patients when co-administered w/ IV Mg sulfate. Concomitant use w/ CYP3A4 inducers or inhibitors. Careful monitoring, & in severe cases, dose reduction in patients w/ impaired liver function. May falsely increase spectrophotometric values of urinary vanillylmandelic acid. May impair ability to drive or operate machinery. Childn <18 yr. Risk of obstructive symptoms. False +ve effect in barium contrast x-ray exam. Should not be used during pregnancy unless necessary. Not recommended during breastfeeding.
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Adverse Reactions
Headache; oedema (including peripheral oedema), vasodilation; constipation; feeling unwell.
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Drug Interactions
Increased exposure w/ CYP3A4 inhibitors eg, macrolide antibiotics (eg, erythromycin), anti-HIV PIs (eg, ritonavir), azole antimycotics (eg, ketoconazole), fluoxetine, nefazodone, quinupristin/dalfopristin, cisapride, valproic acid, cimetidine, diltiazem. Decreased exposure w/ CYP3A4 inducers eg, rifampicin, phenytoin, carbamazepine, phenobarb. Increased BP-lowering effect w/ other antihypertensives. Risk of deterioration of heart failure w/ β-blockers. Reduced clearance & increased plasma level of digoxin. Lowered plasma levels of quinidine. Monitor plasma conc of tacrolimus when co-administered w/ nifedipine; consider reduction in tacrolimus dose. Elevated plasma conc w/ grapefruit juice.
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Caution For Usage
For caution against possible variation of physical aspect of medicine... Click to view Adalat GITS detailed prescribing information
Storage
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Description
View Adalat GITS description for details of the chemical structure and excipients (inactive components).
Action
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MIMS Class
Calcium Antagonists / Anti-Anginal Drugs / Cardiac Drugs
ATC Classification
C08CA05 - nifedipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
Presentation/Packing
Form
Adalat GITS tab 30 mg
Packing/Price
30's
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